Modeling Atopic Dermatitis with Increasingly Complex Mouse Models
نویسندگان
چکیده
منابع مشابه
Recent findings in mouse models for human atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disease, with its major clinical feature being persistent itch sensation in the skin. There are extremely few animal models to reproduce the complicated condition of a patient with AD; therefore researchers have been confronted with some difficulties in pathologic analysis and drug development for AD. Although various models have been propos...
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Hiromichi Yonekawa1, Toyoyuki Takada2, Hiroshi Shitara1, Choji Taya1, Yoshibumi Matsushima3, Kunie Matsuoka4 and Yoshiaki Kikkawa4 1Center for Basic Technology Research Tokyo Metropolitan Institute of Medical Science, Tokyo 2Mammalian Genetics Laboratory, National Institute of Genetics, Mishima 3Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama 4Mammalian Genetics Project...
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Abstract Background and objective: Being exposed to different allergens, followed by the production of specific IgE, has an important role in causing atopic dermatitis, recognizing the allergens and applying immunotherapy for treatment. We aimed to determine the frequency of common allergens in the patients suffering from atopic dermatitis. Material and Methods: In this descriptive- anal...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2008
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5701201